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T19675 |
SM360320
|
CL-087,SM 360320,CL 087,1V136,SM-360320,CL087 |
TLR
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|
SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for ... |
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T17731 |
CL2A-SN-38
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|
Others
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CL2A-SN-38 is a drug-linker conjugate consisting of SN-38, a potent DNA topoisomerase I inhibitor, and linker CL2A, for the manufacture of antibody drug conjugates (ADCs). CL2A-SN-38 provides significant and specific ant... |
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T77551 |
6'-hydroxydihydrocinchonidine
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Antibiotic
,
Drug Metabolite
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6'-hydroxydihydrocinchonidine is a metabolite of quinine, with antimicrobial and antitumor activity, and inhibitory effect on Trypanosoma brucei and Streptococcus pneumoniae. |
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T23867 |
Cdc7-IN-7c
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Cdc7 inhibitor-7c,Cdc7 inhibitor 7c,Cdc7 IN 7c |
CDK
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Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer. |
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T11108 |
DSR-6434
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TLR
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T77688 |
Dipotassium tetrachloroplatinate
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Potassium tetrachloroplatinate |
Others
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Dipotassium tetrachloroplatinate (Potassium tetrachloroplatinate) exhibits antitumor activity in solid tumor lines and can be used in the treatment of oncological diseases. Dipotassium tetrachloroplatinate also acts as a... |
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T13416 |
ZX-29
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ALK
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ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect. |
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T21593 |
AAL-993
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VEGFR
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AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogeni... |
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T3142 |
Drostanolone Propionate
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Others
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Dromostanolone propionate (Drostanolone propionate) is a compound that has antitumor activity against breast carcinoma [1]. Dromostanolone propionate inhibits the uptake of oestradiol-17 by the tumor without apparent eff... |
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T26644 |
Apomine
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SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A |
HMG-CoA Reductase
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|
Apomine (SR-9223i), an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylg... |
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T3317 |
SZL P1-41
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|
Apoptosis
,
Others
,
E1/E2/E3 Enzyme
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SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate... |
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T6960L |
PU-H71 HCl
|
PU-H71 HCl(873436-91-0 Free base),Zelavespib HCl |
HSP
,
DNA/RNA Synthesis
|
|
PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of maligna... |
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T38951 |
Isatuximab
|
SAR-650984,hu38SB19,Isatuximab-irfc |
Apoptosis
,
CD38
|
|
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and extracellular enzyme CD38 in malignant cells of the hematological system and is a highly expressed protein in multiple myeloma. Isatuximab has ... |
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T12009 |
Telomerase-IN-1
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|
Telomerase
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|
Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM). telomerase-IN-1 activates hTERT expression through the endoplasmic reticulum stress (ERS) of the ER overreaction (EOR), which then induces ERS, leading to apopto... |
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T4481 |
Tucidinostat
|
HBI-8000,Chidamide,CS 055 |
HDAC
|
|
Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and sho... |
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T17731L |
CL2A-SN-38 DCA 1279680-68-0(free base)
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|
Others
|
|
CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibito... |
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T36493 |
CMLD-2
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Apoptosis
,
HuR
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CMLD-2 is an inhibitor of HuR-ARE interaction (Ki: 350 nM) that competitively binds HuR protein and disrupts its interaction with adenine element-rich (ARE) mRNA targets.CMLD-2 induces apoptosis and exhibits antitumor ef... |
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T63513 |
Antitumor agent-71
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|
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Antitumor Agent-71 is an antitumor compound that exhibits an inhibitory effect on tubulin aggregation. antitumor Agent-71 possesses an anti-proliferative effect with IC50 values ranging from 3.98-15.70 μM against tumor c... |
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T71655 |
KX1-141
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|
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KX1-141 is an Src-protein tyrosine kinase inhibitor, which may reduce cisplatin ototoxicity while preserving its antitumor effect. |
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T28241 |
Ono 3403
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Ono3403,Ono-3403 |
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|
Ono 3403 is a synthetic serine protease inhibitor. Ono 3403 inhibits lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production. ONO-3403 also has an antitumor effect on malignant tumors. |
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T26413 |
A 30312
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A-30312,A30312 |
|
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A 30312 is a fused indole, which overcomes multidrug resistance in P388/Adr cells in vitro. It potentiates the cytotoxicity of the antitumor drugs Adriamycin, vincristine and vinblastine in multidrug-resistant cells with... |
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T11154 |
EG01377
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Others
|
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EG01377 has antiangiogenic, antimigratory, and antitumor effects.EG01377 is a neuropilin-1 (NRP1) antagonist, with a Kd of 1.32 μM for NRP1-b1, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1, but shows no effect on NRP... |
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T64034 |
Antitumor agent-45
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|
|
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Antitumor agent-45 has an inhibitory effect on c-Met expression and is able to block A549 cells in the G0/G1 and G2/M phases and induce apoptosis. |
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T62510 |
Antitumor agent-75
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|
|
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Antitumor agent-75 is a novel and potent antitumor agent. antitumor agent-75 has cytotoxic effects on cancer and normal human cell lines. antitumor agent-75 in combination with antitumor agent-74 exhibits a highly select... |
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T74439 |
PROTAC SOS1 degrader-1
|
|
|
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PROTAC SOS1 degrader-1, a potent compound, demonstrates an effective degradation of PROTAC SOS1 with a DC50 value of 98.4 nM. It exhibits antiproliferative activity against cancer cells harboring diverse KRAS mutations a... |
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T35613 |
Cytostatin (sodium salt)
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|
|
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Cytostatin (sodium salt) is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectivel... |
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T63810 |
BTK-IN-7
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|
|
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BTK-IN-7 is a selective and potent BTK inhibitor with an IC50 value of 4.0 nM. BTK-IN-7 exhibits high selectivity at both the enzymatic (ITK>250-fold, EGFR>2500-fold) and cellular levels (ITK>227-fold, EGFR27-fold). BTK-... |
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T22631 |
Dolastatin 10 trifluoroacetate
|
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Others
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Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerizati... |
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T79638 |
Lepadin E
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Glutathione Peroxidase
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Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway. By elevating p53 and repressing SLC7A11 and GPX4 expression, it heightens ROS and lipid peroxidation... |
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T69696 |
TAS-108 citrate
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|
|
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TAS-108, also known as SR16234, is a synthetic, antiestrogenic steroidal compound with potential antitumor activity. TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in the mammary gland an... |
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T63324 |
Androgen receptor antagonist 5
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|
|
|
Androgen receptor antagonist 5 is a potent antagonist of the androgen receptor (AR) (IC50: 6.17 μM). Androgen receptor antagonist 5 inhibited the proliferation of prostate cancer cells LNCaP and showed antitumor effect i... |
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T62681 |
PDE5-IN-3
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|
|
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PDE5-IN-3 (compound 11j) is a potent inhibitor of PDE5 (IC50: 1.57 nM). PDE5-IN-3 has a moderate inhibitory effect on EGFR (IC50: 5.827 μM). PDE5-IN-3 markedly inhibits the Wnt/β-catenin pathway with an IC50 value of 128... |
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T73121 |
FGFR4-IN-8
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|
FGFR
|
|
FGFR4-IN-8 (Compound 7v) is an ATP-competitive inhibitor that covalently and highly selectively targets both the wild-type and gatekeeper mutant forms of FGFR4. It shows excellent inhibitory potency with IC50s of 0.5 nM ... |
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T63074 |
Ivaltinostat formic
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|
|
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Ivaltinostat (CG-200745) formic is an oral active panHDAC inhibitor with an isohydroxamic acid component that binds zinc at the bottom of the catalytic pocket. Ivaltinostat formic inhibited the deacetylation of histone H... |
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T68502 |
Dibrospidium Free Base
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|
|
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Dibrospidium Free Base is a dispirotripiperazine derivative and alkylating agent with potential antineoplastic and anti-inflammatory activities. The duration of DNA synthesis inhibition in tumor cells was found to correl... |
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T36539 |
Nocardamine
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|
|
|
Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. b... |
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T11168 |
EHNA hydrochloride
|
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Others
|
|
EHNA hydrochloride is a chemical compound recognized for its antiviral, antitumor, and antiarrhythmic properties. It functions as a potent and selective inhibitor of both cyclic nucleotide phosphodiesterase 2 (PDE2) with... |
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T37861 |
Talabostat
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|
|
|
Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.
Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 ... |
